GM Mosquitoes to Resist Malaria
According to WHO, malaria caused the deaths of nearly one million people in 2008. The proposed solutions from WHO, science, and the Bill and Melinda Gates Foundation tend to center on vaccines, more controlled treatment, and now altering the DNA of mosquitoes to resist the parasite.
The gene in question was successfully passed into mosquito offspring in lab tests. Professor Andrea Crisanti the ideas has been proven in principle, and future focus will be on getting other genes to spread in the same way. “He believes it could be possible to introduce genes which will make the mosquito target animals rather than humans, stop the parasite from multiplying in the insect or produce all male offspring which do not transmit malaria.”
Scientists are quick to assure that they will conduct more studies before the GM mosquitoes integrate into nature. But, GM mosquitoes have already been released into the wild prematurely in two known incidents. The first release took place without approval in the Cayman Islands last year. The other release involved 6,000 GM mosquitoes and was reported earlier this year.
The funded solutions for malaria problems are geared towards vaccines, drugs, or altering the mosquito species forever. It’s always about eradication and changing nature in a lab. Disease, parasites, and pestilence have been a reality since the beginning of time. Natural methods are available to treat illness; better yet, are natural ways to keep the pests from biting in the first place.
GM mosquitoes offer malaria hope
Scientists believe they are closer to being able to change the DNA of wild mosquitoes in order to combat malaria.
In the laboratory, they made a gene spread from a handful of mosquitoes to most of the population in just a few generations, according to a report in Nature.
If the right gene can be made to spread then researchers hope to reduce the number of cases of malaria.
Other academics have described the study as a “major step forward”.
The World Health Organisation estimated that malaria caused nearly one million deaths in 2008.
Research groups have already created “malaria-resistant mosquitoes” using techniques such as introducing genes to disrupt the malaria parasite’s development.
The research, however, has a great challenge – getting those genes to spread from the genetically-modified mosquitoes to the vast number of wild insects across the globe.
Unless the gene gives the mosquito an advantage, the gene will likely disappear.
Scientists at Imperial College London and the University of Washington, in Seattle, believe they have found a solution.They inserted a gene into the mosquito DNA which is very good at looking after its own interests – a homing endonuclease called I-SceI.
The gene makes an enzyme which cuts the DNA in two. The cell’s repair machinery then uses the gene as a template when repairing the cut.
As a result the homing endonuclease gene is copied.
It does this in such a way that all the sperm produced by a male mosquito carry the gene.
So all its offspring have the gene. The process is then repeated so the offspring’s offspring have the gene and so on.
In the laboratory experiments, the gene was spread to half the caged mosquitoes in 12 generations.
- Largely preventable and curable
- In 2008 caused a million deaths – mostly African children
- About 1,500 people return to the UK with malaria every year
- Only 12% of these become seriously ill
- Symptoms can take up to a year to appear
Professor Andrea Crisanti, from the department of life sciences at Imperial College London, said: “This is an exciting technological development, one which I hope will pave the way for solutions to many global health problems.
“At the beginning I was really quite sceptical and thought it probably would not work, but the results are so encouraging that I’m starting to change my mind.”
He said the idea had been proved in principle and was now working on getting other genes to spread in the same way.
He believes it could be possible to introduce genes which will make the mosquito target animals rather than humans, stop the parasite from multiplying in the insect or produce all male offspring which do not transmit malaria.
Professor Janet Hemingway, from the Liverpool School of Tropical Medicine, said the work was an “exciting breakthrough”.
She cautioned that the technique was still some way off being used against wild mosquitoes and there were social issues around the acceptability of using GM technology.
“This is however a major step forward providing technology that may be used in a cost effective format to drive beneficial genes through mosquito populations from relatively small releases,” she added.
Dr Yeya Touré, from the World Health Organisation, said: “This research finding is very important for driving a foreign gene in a mosquito population. However, given that it has been demonstrated in a laboratory cage model, there is the need to conduct further studies before it could be used as a genetic control strategy.”
By James GallagherHealth and Science reporter, BBC News
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